Preheat your oven to 350°F (175°C).
In a mixing bowl, combine flour, sugar, baking powder, pumpkin pie spice, and salt.
In another bowl, whisk together eggs, pumpkin puree, and vanilla extract.
Gradually add the wet ingredients to the dry ingredients, mixing until combined.
Divide the dough in half and shape each half into a log about 12 inches long and 2 inches wide. Place the logs on a baking sheet lined with parchment paper.
Bake for 25-30 minutes, until the logs are firm to the touch. Remove from the oven and let cool for 10 minutes.
Reduce the oven temperature to 300°F (150°C). Slice the logs diagonally into ½-inch thick slices. Place the slices back on the baking sheet, cut side down.
Bake for an additional 10-15 minutes on each side, until the biscotti are dry and crisp. Let cool completely before serving.