Preheat your oven to 350°F (175°C). Line a baking sheet with parchment paper.
In a mixing bowl, whisk together the flour, sugar, baking powder, and salt.
In another bowl, beat the eggs and vanilla extract until combined.
Gradually add the wet ingredients to the dry ingredients, mixing until a dough forms.
Fold in the shredded coconut and chopped macadamia nuts.
Divide the dough in half and shape each half into a log about 10 inches long and 2 inches wide. Place the logs on the prepared baking sheet.
Bake for 25-30 minutes, or until the logs are golden brown. Remove from the oven and let cool for 10 minutes.
Reduce the oven temperature to 325°F (165°C). Using a sharp knife, slice the logs diagonally into ½-inch thick slices.
Place the slices cut side down on the baking sheet and bake for an additional 10-15 minutes, or until the biscotti are crisp and golden. Let cool completely before serving.